Role Of Bacteria In Oral Carcinogenesis

$ 4.08

by Dr. Nidhi Khajuria,Dr. Avneet kour,Dr. Sahul Lerra,Dr. Mohammad Shafi Dar

ISBN Number : 978 – 1- 73029 – 439 – 6

SKU: SBP_2018-02-24-02 Category:


Dr. Nidhi Khajuria
M.D.S oral Pathology .
Registrar, Department of oral Pathology, IGGDC, Jammu,

Dr. Avneet kour
M.D.S oral Surgery
Registrar, Department of oral and Maxillofacial Surgery, IGGDC, Jammu

Dr. Sahul Lerra
M.D.S prosthodontics. Consultant J&k health Services, Jammu

Dr. Mohammad Shafi Dar
M.D.S oral Pathology, Lecturer, Department of oral Pathology. IGGDC. Jammu.

A large number of DNA and RNA viruses have proved to be oncogenic in a wide variety
of animals, ranging from amphibia to primates, and the evidence grows stronger that
certain forms of human cancer are of viral origin.1 Although scientific knowledge in viral
oncology has exploded in the 20th century, the role of bacteria as mediators of
oncogenesis is less well elucidated. Yet for every human cell, the human body carries 10
bacterial cells. How these bacteria might affect disease development in the human host is
rightly a vigorous area of research. As cancer continues its climb as the leading cause of
death in developed nations, understanding the long-term effects of bacteria has become
increasingly important as a possible means of cancer prevention. A transmissible cause of
cancer was suspected as early as the 16th century.

However, it was not until the late 20th century that reproducible, peer-reviewed work
definitively identified a bacterial cause of malignancy.2 Interest in the possible
relationships between bacteria and the different stages of cancer development has been
increasing since the classification by the World Health Organization of Helicobacter
pylori as a definite (class 1)carcinogen (Bjo¨rkholm et al., 2003). Various other bacterial
infections have also been found to correlate with an increased risk of developing cancer,
for instance, an increased risk of gallbladder carcinoma is associated with Salmonella
typhi infection. and there is a greater risk of developing colon cancer in Streptococcus
bovis-infected patients (Ellmerich et al., 2000; Waisberg & Matheus, 2002). The three
main examples are infection with the bacterium Helicobacter pylori leading to an
elevated risk of developing gastric adenocarcinoma and gastric lymphoma, infection
with particular types of human papilloma virus (HPV) leading to cervical cancer, tonsillar
carcinoma and some cases of oral squamous cell carcinoma (OSCC).3 Such
epidemiological links have indirectly implied aetiological roles for these microorganisms,
which has prompted the study of potential mechanisms by which bacterial
species may initiate or promote carcinogenesis.

Additional information

Weight 1.1 kg
Dimensions 1.1 cm